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Abstract

Sirtuin-3 (SIRT3) regulates mitochondrial quality and is involved in the anti-ageing and pro-longevity actions of caloric restriction (CR). Here, we show that CR upregulates the mature form of SIRT3 and mitochondrial intermediate peptidase (MIPEP), a mitochondrial signal peptidase (MtSPase), in white adipose tissue. We also demonstrate that upregulation of mature SIRT3 is dependent on MIPEP in 3T3-L1 cells, suggesting that MIPEP may contribute to the maintenance of mitochondrial quality during CRvia activation of SIRT3. This novel mechanism of SIRT3 activation through MIPEP facilitates the elucidation of additional molecular pathways of CR.

Journal

  • FEBS letters

    FEBS letters 591(24), 4067-4073, 2017

    Wiley

Codes

  • NII Article ID (NAID)
    120006401862
  • NII NACSIS-CAT ID (NCID)
    AA00642943
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    0014-5793
  • Data Source
    IR 
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