Evaluation of the inhibitory effect of N-acetyl-L-cysteine on Babesia and Theileria parasites

• Rizk, Mohamed Abdo.

• El-Sayed, Shimaa Abd El-Salam

• AbouLaila, Mahmoud

• Yokoyama, Naoaki

• Igarashi, Ikuo

Abstract

N-acetyl-L-cysteine is known to have antibacterial, antiviral, antimalarial, and antioxidant activities. Therefore, the in vitro inhibitory effect of this hit was evaluated in the present study on the growth of Babesia and Theileria parasites. The in vitro growth of Babesia bovis, Babesia bigemina, Babesia divergens, Theileria equi, and Babesia caballi that were tested was significantly inhibited (P < 0.05) by micromolar concentrations of N-acetyl-L-cysteine. The inhibitory effect of N-acetyl-L-cysteine was synergistically potentiated when used in combination with diminazene aceturate on B. bovis and B. caballi cultures. These results indicate that N-acetyl-L-cysteine might be used as a drug for the treatment of babesiosis, especially when used in combination with diminazene aceturate. (C) 2017 Elsevier Inc. All rights reserved.

Journal

• Experimental Parasitology

  Experimental Parasitology 179 43-48, 2017-08

  Elsevier

Keywords

• Babesia
• Theileria
• N-acetyl-L-cysteine
• In vitro

Details

• CRID: 1050282812562017408
• NII Article ID: 120006407581
• NII Book ID: AA00641226
• DOI: 10.1016/j.exppara.2017.06.003
• ISSN: 00144894
• Web Site: https://obihiro.repo.nii.ac.jp/records/4170
• Web Site: https://api.elsevier.com/content/article/PII:S0014489416303757?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0014489416303757?httpAccept=text/plain
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN