First clinical isolation report of azole-resistant Aspergillus fumigatus with TR34/L98H-type mutation in Japan
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Recently, azole-resistant Aspergillus fumigatus containing a 34-bp or 46-bp tandem repeat in the promoter region of cyp51A combined with amino acid substitution(s) has appeared in the environment worldwide, including several Asian countries. In this study, we isolated the 34-bp tandem repeat-containing azole-resistant A. fumigatus strain OKH50 from a patient in Japan in May 2016. The patient had not been treated with medical azoles before the strain isolation, suggesting that the resistant property was acquired before infection. In addition, the patient had not traveled overseas. Our analysis of short tandem repeats of the strain indicates that the strain is strongly related to the 34-bp tandem repeat-containing isolates from European countries and Asia-Oceania countries but not to susceptible isolates from Japan, suggesting that the strain was introduced from overseas and might spread in Japan. c 2016 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases
収録刊行物
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- Journal of Infection and Chemotherapy
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Journal of Infection and Chemotherapy 23 (8), 579-581, 2017
Elsevier B.V.
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詳細情報 詳細情報について
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- CRID
- 1050564287538729088
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- NII論文ID
- 120006407583
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- NII書誌ID
- AA11057978
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- ISSN
- 1341321X
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB
- CiNii Articles