Effects of alpha-adrenergic agonists on pain modulation in diffuse noxious inhibitory control
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- 真田 達夫
- Section of Anesthesiology and Clinical Physiology, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University
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- 小長谷 光
- Section of Anesthesiology and Clinical Physiology, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University
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- 牧野 兼三
- Section of Anesthesiology and Clinical Physiology, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University
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- 海野 雅浩
- Section of Anesthesiology and Clinical Physiology, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University
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Background: Diffuse noxious inhibitory control (DNIC) is thought to be mediated by neural networks in supraspinal brain structures. The descending antinociceptive system (DAS) is an important component of the DNIC neural network, but the precise structure of the neural network and the related neurotransmitters have not been examined. Methods: The study was designed to examine whether systemic administration of the adrenergic agonists dexmedetomidine (DEX) and phenylephrine (PE) influences DNIC in the rat. Changes in the C-fiber reflex evoked by electromyographic activity were recorded following noxious tail immersion in hot water. Results: Inhibition of the C-fiber reflex by the conditioning stimuli was reduced from 77.1 ± 22.6% to 26.6 ± 38.2% with continuous administration of DEX, and restored to 58.3 ± 29.2% by intramuscular injection of atipamezole hydrochloride(APZ), a selective α 2- adrenoceptor antagonist. Inhibition of the C-fiber reflex was reduced from 75.6 ± 25.8% to 22.7 ± 38.9% with continuous administration of PE, and restored to 84.9 ± 9.7% by intramuscular injection of phentolamine mesylate (PT), an α - adrenoceptor antagonist. Conclusion: The results show that clinical doses of DEX and PE inhibit DNIC, thereby aff ecting and modulating the intrinsic pain inhibition system. These findings suggest that adrenergic neurons are involved in DNIC.
収録刊行物
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- Journal of Medical and Dental Sciences
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Journal of Medical and Dental Sciences 56 (1), 17-24, 2009
国立大学法人 東京医科歯科大学
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詳細情報 詳細情報について
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- CRID
- 1390001205517724544
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- NII論文ID
- 120006409939
- 130005420266
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- NII書誌ID
- AA12028964
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- ISSN
- 21859132
- 13428810
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- Web Site
- http://id.nii.ac.jp/1569/00000103/
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- 本文言語コード
- en
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- JaLC
- IRDB
- CiNii Articles
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