全身性アミロイドーシス検索薬125I-EISBの研究 : 最適反応時間および安定性の検討  [in Japanese] Study of 125I-EISB for Detecting Systematic Amyloidosis : Evaluation for optimal synthesis time and stability of 125I-EISB  [in Japanese]

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Abstract

1-(2-mestyl-ethoxy) -2,5bis (styryl) benzene (EMSB) is newly synthesized and reacted with 125I with Kripffix222 to obtain 1- (125I-ethoxy) -2,5bis (styryl) benzene (125I-EISB) which is a new amyloid imaging probe that can\image amyloid by Single Photon Emission Computed Tomography (SPECT). The purpose of study is to determine the optimal synthesis time and clarify stability of 125I-EISB in saline and human serum, respectively. We synthesized 125I-EISB and injected 125I-EISB into saline and human serum. We used high performance liquid chromatography (HPLC) to\acquire radiochemical purity of 125I-EISB. We assess changes of radiochemical purity of 125I-EISB over time. As a result, high radioactive purity 95.88±3.19% was obtained in 10 minutes by our synthesis and the radiochemical purity was 97.83±1.40% (n=6) applying our purification system. Radiochemical purity 24 hours later was 94.01±2.09% after injecting in saline. That was 94.23±1.20% after injecting in human serum. From these results, optimal synthesis time was determined 10 minutes and radiochemical purity of 125I-EISB was stably maintained in saline and human serum,\respectively.

Journal

  • 熊本大学医学部保健学科紀要

    熊本大学医学部保健学科紀要 (14), 42-47, 2018-03-31

    熊本大学

Codes

  • NII Article ID (NAID)
    120006411123
  • NII NACSIS-CAT ID (NCID)
    AA12010572
  • Text Lang
    JPN
  • Article Type
    departmental bulletin paper
  • Data Source
    IR 
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