Late Chemotherapy-Induced Nausea and Vomiting after Cisplatin Treatment for Patients with Esophageal or Gastric Cancer

この論文をさがす

抄録

type:TOHO University Scholarly Publication

原著

Background: Chemotherapy-induced nausea and vomiting (CINV) usually resolves within 5 days of chemotherapy initiation. However, some patients have CINV at 6 days or later after chemotherapy initiation (late CINV). We evaluated the incidence of late CINV and the effectiveness of aprepitant plus palonosetron in preventing late CINV. Methods: We retrospectively reviewed the records of 102 patients with esophageal or gastric cancer to determine CINV incidence on days 1 through 21 after initiation of cisplatin treatment. Sixty-six patients received a first-generation 5-hydroxytryptamine (serotonin) type 3 receptor antagonist, and 36 received aprepitant plus palonosetron. In addition, we compared the effectiveness of antiemetic regimens before and after administering aprepitant and palonosetron. CINV was defined as presence of grade 1 or higher vomiting or grade 2 or higher nausea. Results: In the aprepitant plus palonosetron group, the highest incidence of CINV (42%) was seen at 7 days after initiation of cisplatin treatment. CINV incidence started to gradually decrease at 8 days after cisplatin initiation. There was no significant intergroup difference in the incidence of late CINV. Conclusions: Late CINV may develop in patients receiving cisplatin for treatment of esophageal or gastric cancer. Our findings suggest that the widely used prophylaxis for delayed CINV resulting from highly emetogenic chemotherapy is not satisfactorily effective against late CINV. 背景と目的:抗がん剤により引き起こされる嘔気・嘔吐(chemotherapy-induced nausea and vomiting:CINV)は,投与後5日以内に消失すると考えられている.しかし,6日目以降も嘔気を訴える「超遅発性CINV」の患者も散見される.超遅発性CINVの発現頻度と,アプレピタント+パロノセトロンの制吐効果を調査した.対象および方法:食道癌または胃癌の患者102名を対象に,シスプラチン投与後21日間のCINV発現頻度を後ろ向きに調査した.アプレピタント+パロノセトロンの採用前後での制吐療法の効果も比較した.結果:アプレピタント+パロノセトロン群では,シスプラチン投与後7日目にCINV発現頻度が最高値(42%)となった.超遅発性期では,2群間の制吐効果に有意差はなかった.結論:シスプラチン投与を受ける食道癌または胃癌患者において,超遅発性CINVが存在することが示された.広く使われている制吐療法が,超遅発性CINVに対しては効果が十分ではないことが示唆された.

収録刊行物

詳細情報

問題の指摘

ページトップへ