iPSC technology-based regenerative therapy for diabetes
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- Kondo, Yasushi
- Center for iPS Cell Research and Application (CiRA), Kyoto University・Department of Diabetes, Endocrinology and Nutrition, Kyoto University
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- Toyoda, Taro
- Center for iPS Cell Research and Application (CiRA), Kyoto University
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- Inagaki, Nobuya
- Department of Diabetes, Endocrinology and Nutrition, Kyoto University
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- Osafune, Kenji
- Center for iPS Cell Research and Application (CiRA), Kyoto University
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Abstract
The directed differentiation of human pluripotent stem cells, such as embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs), into pancreatic endocrine lineages has been vigorously examined by reproducing the in vivo developmental processes of the pancreas. Recent advances in this research field have enabled the generation from hESCs/iPSCs of functionally mature β‐like cells in vitro that show glucose‐responsive insulin secretion ability. The therapeutic potentials of hESC/iPSC‐derived pancreatic cells have been evaluated using diabetic animal models, and transplantation methods including immunoprotective devices that prevent immune responses from hosts to the implanted pancreatic cells have been investigated towards the development of regenerative therapies against diabetes. These efforts led to the start of a clinical trial that involves the implantation of hESC‐derived pancreatic progenitors into type 1 diabetes patients. In addition, patient‐derived iPSCs have been generated from diabetes‐related disorders towards the creation of novel in vitro disease models and drug discovery, although few reports so far have analyzed the disease mechanisms. Considering recent advances in differentiation methods that generate pancreatic endocrine lineages, we will see the development of novel cell therapies and therapeutic drugs against diabetes based on iPSC technology‐based research in the next decade.
Journal
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- Journal of Diabetes Investigation
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Journal of Diabetes Investigation 9 (2), 234-243, 2018-03-04
Blackwell Publishing
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Details 詳細情報について
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- CRID
- 1050564285808301568
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- NII Article ID
- 120006454662
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- ISSN
- 20401124
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- HANDLE
- 2433/230423
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- IRDB
- CiNii Articles