Iron chelators inhibit the heme-degradation reaction by HutZ from Vibrio cholerae

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Abstract

HutZ is a heme-degrading enzyme. We found that the heme-degradation reaction by HutZ is inhibited by the iron chelators. Kinetic analysis of each heme-degradation step suggests that water molecules hydrogen bonded to Thr27 are involved in proton transfer to Fe(III)-OO-, and that this step is inhibited by iron chelators.

Journal

  • Dalton transactions

    Dalton transactions 46 (16), 5147-5150, 2017-04-28

    Royal Society of Chemistry

Details 詳細情報について

  • CRID
    1050282813999731584
  • NII Article ID
    120006459301
  • NII Book ID
    AA11810256
  • ISSN
    14779234
    14779226
  • HANDLE
    2115/70026
  • Text Lang
    en
  • Article Type
    journal article
  • Data Source
    • IRDB
    • CiNii Articles

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