Iron chelators inhibit the heme-degradation reaction by HutZ from Vibrio cholerae
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Abstract
HutZ is a heme-degrading enzyme. We found that the heme-degradation reaction by HutZ is inhibited by the iron chelators. Kinetic analysis of each heme-degradation step suggests that water molecules hydrogen bonded to Thr27 are involved in proton transfer to Fe(III)-OO-, and that this step is inhibited by iron chelators.
Journal
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- Dalton transactions
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Dalton transactions 46 (16), 5147-5150, 2017-04-28
Royal Society of Chemistry
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Details 詳細情報について
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- CRID
- 1050282813999731584
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- NII Article ID
- 120006459301
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- NII Book ID
- AA11810256
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- ISSN
- 14779234
- 14779226
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- HANDLE
- 2115/70026
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- IRDB
- CiNii Articles