The effect of duration of illness and antipsychotics on subcortical volumes in schizophrenia: Analysis of 778 subjects

• 竹村, 有由

  Department of Psychiatry, Hokkaido University Graduate School of Medicine

• 孫, 樹洛

  Department of Biostatistics, Hokkaido University Graduate School of Medicine

• Okada, Naohiro

  Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo

• Yamamori, Hidenaga

  Department of Psychiatry, Osaka University Graduate School of Medicine

• Yasuda, Yuka

  Department of Psychiatry, Osaka University Graduate School of Medicine

• Fujimoto, Michiko

  Department of Psychiatry, Osaka University Graduate School of Medicine

• Kudo, Noriko

  Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University

• Takemura, Ariyoshi

  Department of Psychiatry, Graduate School of Medicine, Kyoto University

• Son, Shuraku

  Department of Psychiatry, Graduate School of Medicine, Kyoto University

• Narita, Hisashi

  Department of Psychiatry, Hokkaido University Graduate School of Medicine

• Yamamoto, Maeri

  Department of Psychiatry, Nagoya University Graduate School of Medicine

• Tha, Khin Khin

  Department of Radiation Medicine, Hokkaido University Graduate School of Medicine

• Katsuki, Asuka

  Department of Psychiatry, University of Occupational and Environmental Health

• Ohi, Kazutaka

  Department of Neuropsychiatry, Kanazawa Medical University

• Yamashita, Fumio

  Division of Ultrahigh Field MRI, Institute for Biomedical Sciences, Iwate Medical University

• Koike, Shinsuke

  Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo・Office for Mental Health Support, Division for Counseling and Support, The University of Tokyo

• Takahashi, Tsutomu

  Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences

• Nemoto, Kiyotaka

  Department of Neuropsychiatry, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba

• Fukunaga, Masaki

  Division of Cerebral Integration, National Institute for Physiological Sciences

• Onitsuka, Toshiaki

  Department of Neuropsychiatry, Graduate School of Medical Sciences

• Watanabe, Yoshiyuki

  Department of Radiology, Osaka University Graduate School of Medicine

• Yamasue, Hidenori

  Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo・Department of Psychiatry, Hamamatsu University School of Medicine

• Suzuki, Michio

  Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences

• Kasai, Kiyoto

  Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo

• Kusumi, Ichiro

  Department of Psychiatry, Hokkaido University Graduate School of Medicine

• Hashimoto, Ryota

  Department of Psychiatry, Osaka University Graduate School of Medicine・Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University

• COCORO

抄録

Bachground: The effect of duration of illness and antipsychotic medication on the volumes of subcortical structures in schizophrenia is inconsistent among previous reports. We implemented a large sample analysis utilizing clinical data from 11 institutions in a previous meta-analysis. Methods: Imaging and clinical data of 778 schizophrenia subjects were taken from a prospective meta-analysis conducted by the COCORO consortium in Japan. The effect of duration of illness and daily dose and type of antipsychotics were assessed using the linear mixed effect model where the volumes of subcortical structures computed by FreeSurfer were used as a dependent variable and age, sex, duration of illness, daily dose of antipsychotics and intracranial volume were used as independent variables, and the type of protocol was incorporated as a random effect for intercept. The statistical significance of fixed-effect of dependent variable was assessed. Results: Daily dose of antipsychotics was positively associated with left globus pallidus volume and negatively associated with right hippocampus. It was also positively associated with laterality index of globus pallidus. Duration of illness was positively associated with bilateral globus pallidus volumes. Type of antipsychotics did not have any effect on the subcortical volumes. Discussion: A large sample size, uniform data collection methodology and robust statistical analysis are strengths of the current study. This result suggests that we need special attention to discuss about relationship between subcortical regional brain volumes and pathophysiology of schizophrenia because regional brain volumes may be affected by antipsychotic medication.

収録刊行物

• NeuroImage: Clinical

  NeuroImage: Clinical 17 563-569, 2018

  Elsevier BV

キーワード

• Schizophrenia
• MRI
• Globus pallidus
• Hippocampus
• Antipsychotic
• Duration of illness

詳細情報

• CRID: 1050001335857441792
• NII論文ID: 120006463564
• NII論文ID: 120006460075
• ISSN: 22131582
• DOI: 10.1016/j.nicl.2017.11.004
• HANDLE: 2433/230809
• HANDLE: 2115/70164
• Web Site: https://api.elsevier.com/content/article/PII:S221315821730284X?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S221315821730284X?httpAccept=text/plain
• 本文言語コード: en
• 資料種別: journal article
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