RNA-DNA Triplex Formation by Long Noncoding RNAs

HANDLE Open Access
  • Li, Yue
    Department of Chemistry, Graduate School of Science, Kyoto University
  • Syed, Junetha
    Department of Chemistry, Graduate School of Science, Kyoto University
  • Sugiyama, Hiroshi
    Department of Chemistry, Graduate School of Science, Kyoto University・Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University

Abstract

Long noncoding RNAs (lncRNAs) play a pivotal role in the regulation of biological processes through various mechanisms that are not fully understood. Proposed mechanisms include regulation based on RNA-protein interactions, as well as RNA-RNA interactions and RNA-DNA interactions. Here, we focus on one possible mechanism that lncRNA might be using to impact biological function, the RNA-DNA triplex formation. We summarize currently available examples of lncRNA triplex formation and discuss the details surrounding orientation of triplex formation as one of the key properties guiding this process. We propose that symmetrical triplex-forming motifs, especially those in cis-acting lncRNAs, favor triplex formation. We also consider the effects of lncRNA structures, protein or ligand binding, and chromatin structures on the lncRNAs triplex formation.

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Keywords

Details 詳細情報について

  • CRID
    1050564285810881408
  • NII Article ID
    120006460082
  • ISSN
    24519456
  • HANDLE
    2433/230817
  • Text Lang
    en
  • Article Type
    journal article
  • Data Source
    • IRDB
    • CiNii Articles

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