Close pathological correlations between chronic kidney disease and reproductive organ-associated abnormalities in female cotton rats

• Ichii, Osamu

• Nakamura, Teppei

• Irie, Takao

• Kouguchi, Hirokazu

• Sotozaki, Kozue

• Horino, Taro

• Sunden, Yuji

• Elewa, Yaser Hosny Ali

• Kon, Yasuhiro

抄録

Cotton rat (Sigmodon hispidus) is a useful experimental rodent for the study of human infectious diseases. We previously clarified that cotton rats, particularly females, developed chronic kidney disease characterized by cystic lesions, inflammation, and fibrosis. The present study investigated female-associated factors for chronic kidney disease development in cotton rats. Notably, female cotton rats developed separation of the pelvic symphysis and hypertrophy in the vaginal parts of the cervix with age, which strongly associated with pyometra. The development of pyometra closely associated with the deterioration of renal dysfunction or immunological abnormalities was indicated by blood urea nitrogen and serum creatinine or spleen weight and serum albumin/globulin ratio, respectively. These parameters for renal dysfunction and immunological abnormalities were statistically correlated. These phenotypes found in the female reproductive organs were completely inhibited by ovariectomy. Further, the female cotton rats with pyometra tended to show more severe chronic kidney disease phenotypes and immunological abnormalities than those without pyometra; these changes were inhibited in ovariectomized cotton rats. With regard to renal histopathology, cystic lesions, inflammation, and fibrosis were ameliorated by ovariectomy. Notably, the immunostaining intensity of estrogen receptor and estrogen receptor were weak in the healthy kidneys, but both estrogen receptors were strongly induced in the renal tubules showing cystic changes. In conclusion, the close correlations among female reproductive organ-associated abnormalities, immunological abnormalities, and renal dysfunction characterize the chronic kidney disease features of female cotton rats. Thus, the cotton rat is a unique rodent model to elucidate the pathological crosstalk between chronic kidney disease and sex-related factors.

収録刊行物

• Experimental biology and medicine

  Experimental biology and medicine 243 (5), 418-427, 2018-03

  SAGE Publications

キーワード

• Cotton rat
• chronic kidney disease
• sex hormone
• pyometra
• ovariectomy
• histopathology

詳細情報

• CRID: 1050001202675144320
• NII論文ID: 120006484261
• HANDLE: 2115/70867
• ISSN: 15353702
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles