Early expression of serum CCL8 closely correlates to non-relapse mortality after allogeneic hematopoietic stem cell transplantation
Search this article
Abstract
To explore the role of Chemokine (C-C motif) ligand 8 (CCL8) as a potential biomarker for acute graft-versus-host disease (aGVHD), we retrospectively analyzed the sera and clinical course of 31 patients with grade II–IV aGVHD. No deaths occurred in the ten patients with serum CCL8 concentrations less than 213 pg/mL, whereas 11 of the 21 patients with more than 213 pg/mL died within 180 days post-transplantation. This landmark analysis revealed a significantly lower urvival rate of patients with a CCL8 serum concentration greater than 213 pg/mL. Thus, elevated serum CCL8 concentration before day 100 post-transplantation may predict aGVHD prognosis
Journal
-
- 札幌医学雑誌 = The Sapporo Medical Journal
-
札幌医学雑誌 = The Sapporo Medical Journal 86 (1-6), 45-51, 2017
札幌医科大学医学部
- Tweet
Details 詳細情報について
-
- CRID
- 1390290699788696192
-
- NII Article ID
- 120006488957
-
- NII Book ID
- AN00097280
-
- NDL BIB ID
- 028997124
-
- ISSN
- 0036472X
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- IRDB
- NDL
- CiNii Articles
-
- Abstract License Flag
- Allowed