Development of an Anilide-Type Scaffold for the Thioester Precursor N-Sulfanylethylcoumarinyl Amide
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N-Sulfanylethylcoumarinyl amide (SECmide) peptide, which was initially developed for the use in the fluorescence-guided detection of promoters of N–S acyl transfer, was successfully applied to a facile and side reaction-free protocol for N–S acyl-transfer-mediated synthesis of peptide thioesters. Additionally, 4-mercapto benzyl phosphonic acid (MBPA) was proved to be a useful catalyst for the SECmide or N-sulfanylethylanilide (SEAlide)-mediated NCL reaction.
- Organic Letters
Organic Letters 18(17), 4416-4419, 2016-08-16