The total chemical synthesis of the monoglycosylated GM2 ganglioside activator using a novel cysteine surrogate

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Abstract

We describe a novel peptide ligation/desulfurization strategy using β-mercapto-N-glycosylated asparagine derivative. The newly developed procedure is successfully applied to total chemical synthesis of GM2 ganglioside activator protein bearing a monosaccharide on the native glycosylation site.

Journal

  • Chemical Communications

    Chemical Communications 51(49), 9946-9948, 2015-05-13

    The Royal Society of Chemistry

Codes

  • NII Article ID (NAID)
    120006489006
  • NII NACSIS-CAT ID (NCID)
    AA11071130
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    1359-7345
  • Data Source
    IR 
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