The total chemical synthesis of the monoglycosylated GM2 ganglioside activator using a novel cysteine surrogate
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We describe a novel peptide ligation/desulfurization strategy using β-mercapto-N-glycosylated asparagine derivative. The newly developed procedure is successfully applied to total chemical synthesis of GM2 ganglioside activator protein bearing a monosaccharide on the native glycosylation site.
- Chemical Communications
Chemical Communications 51(49), 9946-9948, 2015-05-13
The Royal Society of Chemistry