Intrinsic Projections of Layer Vb Neurons to Layers Va, III, and II in the Lateral and Medial Entorhinal Cortex of the Rat

• Ohara, Shinya

  Division of Systems Neuroscience, Tohoku University Graduate School of Life Sciences・Kavli institute for Systems Neuroscience, Center for Computational Neuroscience, Egil and Pauline Braathen and Fred Kavli Center for Cortical Microcircuits, NTNU Norwegian University of Science and Technology

• Onodera, Mariko

  Division of Systems Neuroscience, Tohoku University Graduate School of Life Sciences

• Simonsen, Øyvind W.

  Kavli institute for Systems Neuroscience, Center for Computational Neuroscience, Egil and Pauline Braathen and Fred Kavli Center for Cortical Microcircuits, NTNU Norwegian University of Science and Technology

• Yoshino, Rintaro

  Division of Systems Neuroscience, Tohoku University Graduate School of Life Sciences

• Hioki, Hiroyuki

  Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University・Department of Cell Biology and Neuroscience, Juntendo University Graduate School of Medicine

• Iijima, Toshio

  Division of Systems Neuroscience, Tohoku University Graduate School of Life Sciences

• Tsutsui, Ken-Ichiro

  Division of Systems Neuroscience, Tohoku University Graduate School of Life Sciences

• Witter, Menno P.

  Kavli institute for Systems Neuroscience, Center for Computational Neuroscience, Egil and Pauline Braathen and Fred Kavli Center for Cortical Microcircuits, NTNU Norwegian University of Science and Technology

Abstract

Layer V of the entorhinal cortex (EC) receives input from the hippocampus and originates main entorhinal outputs. The deep-sublayer Vb, immunopositive for the transcription factor Ctip2, is thought to be the main recipient of hippocampal projections, whereas the superficial-sublayer LVa, immunonegative for Ctip2, originates the main outputs of EC. This disrupts the proposed role of EC as mediating hippocampal-cortical interactions. With the use of specific (trans)synaptic tracing approaches, we report that, in medial entorhinal cortex, layer Vb neurons innervate neurons in layers Va, II, and III. A similar circuitry exists in the lateral entorhinal cortex. We conclude that EC-layer Vb neurons mediate two circuits in the hippocampus-memory system: (1) a hippocampal output circuit to telencephalic areas by projecting to layer Va and (2) a feedback projection, sending information back to the EC-hippocampal loop via neurons in layers II and III.

Journal

• Cell Reports

  Cell Reports 24 (1), 107-116, 2018-07-03

  Elsevier BV

Keywords

• parahippocampus
• rodent
• interlaminar connectivity
• hippocampal-entorhinal connections
• hippocampal-cortical connections

Details

• CRID: 1050282810836964992
• NII Article ID: 120006491716
• ISSN: 22111247
• DOI: 10.1016/j.celrep.2018.06.014
• HANDLE: 2433/232698
• Web Site: https://api.elsevier.com/content/article/PII:S2211124718309094?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S2211124718309094?httpAccept=text/plain
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN