Mild hyperbaric oxygen inhibits the decrease of dopaminergic neurons in the substantia nigra of mice with MPTP-induced Parkinson's disease
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- 石原, 昭彦
- Laboratory of Cell Biology and Life Science, Graduate School of Human and Environmental Studies, Kyoto University
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- Takemura, Ai
- Laboratory of Cell Biology and Life Science, Graduate School of Human and Environmental Studies, Kyoto University
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- Nakano, Masaki
- Laboratory of Functional Biology, Graduate School of Biostudies, Kyoto University
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- Ishihara, Akihiko
- Laboratory of Cell Biology and Life Science, Graduate School of Human and Environmental Studies, Kyoto University
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抄録
We examined whether exposure to mild hyperbaric oxygen inhibits the decrease of dopaminergic neurons in the substantia nigra of a neurotoxic animal model with Parkinson’s disease. Mice injected with 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine hydrochloride and probenecid twice a week were divided into two groups: mice with mild hyperbaric oxygen and those without. The mice with mild hyperbaric oxygen were exposed to 1317 hPa with 45% oxygen for 3 h, three times a week. The decrease in dopaminergic neurons of mice with Parkinson’s disease was inhibited by 11 weeks of exposure to mild hyperbaric oxygen. We conclude that exposure to mild hyperbaric oxygen is effective in preventing the progression of Parkinson’s disease.
収録刊行物
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- Neuroscience Research
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Neuroscience Research 132 58-62, 2018-07
Elsevier Ireland Ltd
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詳細情報 詳細情報について
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- CRID
- 1050564285813677056
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- NII論文ID
- 120006491719
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- ISSN
- 01680102
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- HANDLE
- 2433/232712
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB
- CiNii Articles