Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis

• 鈴木, 栄治

  Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam

• Babes, Liane

  Immunology Research Group, University of Calgary

• Zhao, Xi Wen

  Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam

• van Houdt, Michel

  Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam

• Treffers, Louise W.

  Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam

• van Rees, Dieke J.

  Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam

• Franke, Katka

  Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam

• Schornagel, Karin

  Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam

• Verkuijlen, Paul

  Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam

• Janssen, Hans

  Division of Cell Biology, the Netherlands Cancer Institute

• Halonen, Pasi

  Division of Molecular Carcinogenesis and the NKI Robotics and Screening Center, the Netherlands Cancer Institute

• Lieftink, Cor

  Division of Molecular Carcinogenesis and the NKI Robotics and Screening Center, the Netherlands Cancer Institute

• Beijersbergen, Roderick L.

  Division of Molecular Carcinogenesis and the NKI Robotics and Screening Center, the Netherlands Cancer Institute

• Leusen, Jeanette H.W.

  Immunotherapy Laboratory, Laboratory for Translational Immunology, University Medical Center Utrecht

• Boelens, Jaap J.

  U-DANCE, Laboratory for Translational Immunology, UMC Utrecht・Department of Pediatrics, Blood and Marrow Transplantation Program, UMC Utrecht

• Kuhnle, Ingrid

  Department of Pediatrics, University Medicine Göttingen

• van der Werff Ten Bosch, Jutte

  Department of Pediatrics, Universitair Ziekenhuis Brussel

• Seeger, Karl

  Department of Pediatric Oncology/Hematology, Otto-Heubner-Center for Pediatric and Adolescent Medicine, Charité-Universitätsmedizin Berlin

• Rutella, Sergio

  Division of Translational Medicine, Sidra Medical and Research Center

• Pagliara, Daria

  Department of Pediatric Hematology/Oncology, IRCCS Bambino Gesù Children’s Hospital

• Matozaki, Takashi

  Department of Biochemistry and Molecular Biology, Division of Molecular and Cellular Signaling, Kobe University Graduate School of Medicine

• Suzuki, Eiji

  Department of Breast Surgery, Kyoto University Hospital

• Menke-van der Houven van Oordt, Catharina Willemien

  Department of Medical Oncology, VU University Medical Center

• van Bruggen, Robin

  Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam

• Roos, Dirk

  Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam

• van Lier, Rene A.W.

  Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam

• Kuijpers, Taco W.

  Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam・Emma Children’s Hospital, Academic Medical Centre, University of Amsterdam

• Kubes, Paul

  Immunology Research Group, University of Calgary

• van den Berg, Timo K.

  Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam・Department of Molecular Cell Biology and Immunology, VU Medical Center, Amsterdam

抄録

Destruction of cancer cells by therapeutic antibodies occurs, at least in part, through antibody-dependent cellular cytotoxicity (ADCC), and this can be mediated by various Fc-receptor-expressing immune cells, including neutrophils. However, the mechanism(s) by which neutrophils kill antibody-opsonized cancer cells has not been established. Here, we demonstrate that neutrophils can exert a mode of destruction of cancer cells, which involves antibody-mediated trogocytosis by neutrophils. Intimately associated with this is an active mechanical disruption of the cancer cell plasma membrane, leading to a lytic (i.e., necrotic) type of cancer cell death. Furthermore, this mode of destruction of antibody-opsonized cancer cells by neutrophils is potentiated by CD47-SIRPα checkpoint blockade. Collectively, these findings show that neutrophil ADCC toward cancer cells occurs by a mechanism of cytotoxicity called trogoptosis, which can be further improved by targeting CD47-SIRPα interactions.

収録刊行物

• Cell Reports

  Cell Reports 23 (13), 3946-3959, 2018-06-26

  Elsevier BV

キーワード

• antibody-dependent cellular cytotoxicity
• neutrophils
• CD47-SIRPα interaction
• trogocytosis
• trogoptosis

詳細情報

• CRID: 1050564285813733120
• NII論文ID: 120006491924
• ISSN: 22111247
• HANDLE: 2433/232950
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles