Use of Tricyclic Antidepressants as Analgesic Adjuvants Results in Nonhazardous Prolongation of the QTc Interval

• Funai, Yusuke

• Funao, Tomoharu

• Ikenaga, Kazutake

• Takahashi, Ryota

• Hase, Ichiro

• Nishikawa, Kiyonobu

Abstract

Background : Tricyclic antidepressants (TCAs) are known to prolong QTc interval. However, little is known about the QTc lengthening effect of TCAs at analgesic dosages and the predictive factors for abnormal QTc prolongation. / Methods : We conducted a single-center, retrospective observational study, and evaluated 87 patients (65 amitriptyline, 22 nortriptyline) who underwent 12-lead electrocardiogram (ECG) examinations both before and after receiving TCAs for herpes zoster pain or postherpetic neuralgia from May 2007 to January 2012. Data on QTc interval, age, gender, the type and daily dosage of TCAs, the medication period until the second ECG examination, and ECG findings were obtained from electronic medical charts....

Journal

• Osaka City Medical Journal

  Osaka City Medical Journal 60 (1), 11-19, 2014-06

  OSAKA CITY MEDICAL ASSOCIATION

Keywords

• QTc prolongation
• Tricyclic antidepressants
• Electrocardiogram
• Analgesic adjuvant

Details

• CRID: 1050001202452443520
• NII Article ID: 120006493304
• NII Book ID: AA00765896
• ISSN: 00306096
• Web Site: https://dlisv03.media.osaka-cu.ac.jp/il/meta_pub/G0000438repository_00306096-60-1-11
• Web Site: https://search.jamas.or.jp/link/ui/2020012972
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles
  • KAKEN