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Abstract

A fluoride-responsive (FR) amino acid that induces amide bond cleavage upon the addition of a fluoride was developed, and it was applied to a FR traceable linker. By the use of an alkyne-containing peptide as a model of an alkynylatd target protein of a bioactive compound, introduction of the FR traceable linker onto the peptide was achieved. Subsequent fluoride induced cleavage of the linker followed by labeling of the released peptide derivative was also conducted to examine the potential applicability of the FR traceable linker to the enrichment and labeling of alkynylated target molecules.

Journal

  • Tetrahedron

    Tetrahedron 70(34), 5122-5127, 2014-06-06

    Elsevier Ltd.

Codes

  • NII Article ID (NAID)
    120006493358
  • NII NACSIS-CAT ID (NCID)
    AA00861787
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    0040-4020
  • Data Source
    IR 
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