Development of a Reduction‐Responsive Amino Acid that Induces Peptide Bond Cleavage in Hypoxic Cells

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Abstract

Utilization of a hypoxia-responsive amino acid is indispensable in the preparation of hypoxic tumor-specific peptidyl prodrugs. Bioreduction of a nitro group is among the most attractive triggering reactions in the hypoxia-responsive prodrugs. In this paper, design and synthesis of a reduction-responsive amino acid that induces peptide bond cleavage after reduction of the nitro group are described. Application to hypoxia-responsive peptide bond cleavage system is also reported.

Journal

  • ChemBioChem

    ChemBioChem 13(7), 968-971, 2012-04-13

    WILEY‐VCH Verlag GmbH & Co. KGaA

Codes

  • NII Article ID (NAID)
    120006493361
  • NII NACSIS-CAT ID (NCID)
    AA11617132
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    1439-7633
  • Data Source
    IR 
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