Development of a traceable linker containing a thiol-responsive amino acid for the enrichment and selective labelling of target proteins

• Yamamoto, Jun

• Denda, Masaya

• Maeda, Nami

• Kita, Miku

• Komiya, Chiaki

• Tanaka, Tomohiro

• Nomura, Wataru

• Tamamura, Hirokazu

• Sato, Youichi

• Yamauchi, Aiko

• Shigenaga, Akira

• Otaka, Akira

Abstract

A traceable linker that is potentially applicable to identification of a target protein of bioactive compounds was developed. It enabled not only thiol-induced cleavage of the linker for enrichment of the target protein but also selective labelling to pick out the target from contaminated non-target proteins for facile identification.

Journal

• Organic & Biomolecular Chemistry

  Organic & Biomolecular Chemistry 12 (23), 3821-3826, 2014-04-17

  The Royal Society of Chemistry

Keywords

• Organic Chemistry
• Physical and Theoretical Chemistry
• Biochemistry

Details

• CRID: 1050282812711364480
• NII Article ID: 120006510952
• NII Book ID: AA1168650X
• ISSN: 14770520
• ISSN: 14770539
• DOI: 10.1039/c4ob00622d
• Web Site: http://repo.lib.tokushima-u.ac.jp/111911
• Web Site: http://pubs.rsc.org/en/content/articlepdf/2014/OB/C4OB00622D
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN