Cell competition in mammals — novel homeostatic machinery for embryonic development and cancer prevention

• Maruyama, Takeshi

• Fujita, Yasuyuki

書誌事項

タイトル別名

• Cell competition in mammals : novel homeostatic machinery for embryonic development and cancer prevention

抄録

In the multi-cellular community, cells with different properties often compete with each other for survival and space. This process is named cell competition and was originally discovered in Drosophila. Recent studies have revealed that comparable phenomena also occur in mammals under various physiological and pathological conditions. Within the epithelium, normal cells often recognize the presence of the neighboring transformed cells and actively eliminate them from the epithelium; a process termed EDAC (Epithelial Defense Against Cancer). Furthermore, physical force can play a crucial role in the intercellular recognition and elimination of loser cells during cell competition. Further studies are expected to reveal a variety of roles of cell competition in embryonic development and human diseases.

収録刊行物

• Current opinion in cell biology

  Current opinion in cell biology 48 106-112, 2017-10

  Elsevier

キーワード

• Cell Biology

詳細情報

• CRID: 1050001202927849856
• NII論文ID: 120006523718
• DOI: 10.1016/j.ceb.2017.06.007
• HANDLE: 2115/71578
• ISSN: 09550674
• Web Site: https://api.elsevier.com/content/article/PII:S095506741630179X?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S095506741630179X?httpAccept=text/plain
• 本文言語コード: en
• 資料種別: journal article
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