Dynamics and function of <scp>ERM</scp> proteins during cytokinesis in human cells

• Hiruma, Shota

• Kamasaki, Tomoko

• Otomo, Kohei

• Nemoto, Tomomi

• Uehara, Ryota

書誌事項

タイトル別名

• Dynamics and function of ERM proteins during cytokinesis in human cells

抄録

The molecular mechanism that governs cytoskeleton-membrane interaction during animal cytokinesis remains elusive. Here, we investigated the dynamics and functions of ERM (Ezrin/Radixin/Moesin) proteins during cytokinesis in human cultured cells. We found that ezrin is recruited to the cleavage furrow through its membrane-associated domain in a cholesterol-dependent but largely Rho-independent manner. While ERMs are dispensable for furrow ingression, they play a pivotal role in contractile activity of the polar cortex. Notably, when anillin and supervillin are codepleted, ERMs increasingly accumulate at the cleavage furrow and substantially contribute to the furrow ingression. These results reveal a supportive role of ERMs in cortical activities during cytokinesis, and also provide insight into the selective mechanism that preferentially associates cytokinesis-relevant proteins with the division site.

収録刊行物

• FEBS Letters

  FEBS Letters 591 (20), 3296-3309, 2017-10-26

  Wiley

キーワード

• Cell Biology
• Genetics
• Molecular Biology
• Biochemistry
• Structural Biology
• Biophysics

詳細情報

• CRID: 1050001339054481024
• NII論文ID: 120006533122
• DOI: 10.1002/1873-3468.12844
• ISSN: 18733468
• ISSN: 00145793
• HANDLE: 2115/71760
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2F1873-3468.12844
• Web Site: https://febs.onlinelibrary.wiley.com/doi/pdf/10.1002/1873-3468.12844
• 本文言語コード: en
• 資料種別: journal article
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