Tetraploidy-associated centrosome overduplication in mouse early embryos

• Yaguchi, Kan

• Yamamoto, Takahiro

• Matsui, Ryo

• Shimada, Masaya

• Shibanuma, Atsuko

• Kamimura, Keiko

• Koda, Toshiaki

• Uehara, Ryota

抄録

Recently, we observed that tetraploidization of certain types of human cancer cells resulted in upregulation of centrosome duplication cycles and chronic generation of the extra centrosome. Here, we investigated whether tetraploidy-linked upregulation of centrosome duplication also occurs in non-cancer cells using tetraploidized parthenogenetic mouse embryos. Cytokinesis blockage at early embryonic stage before de novo centriole biogenesis provided the unique opportunity in which tetraploidization can be induced without transient doubling of centrosome number. The extra numbers of the centrioles and the centrosomes were observed more frequently in tetraploidized embryos during the blastocyst stage than in their diploid counterparts, demonstrating the generality of the newly found tetraploidy-driven centrosome overduplication in mammalian non-cancer systems.

収録刊行物

• Communicative & Integrative Biology

  Communicative & Integrative Biology 11 (4), e1526605-1-e1526605-4, 2018-10-02

  Informa UK Limited

キーワード

• Tetraploid
• centrosome
• mouse embryo

詳細情報

• CRID: 1050001339054579328
• NII論文ID: 120006533159
• DOI: 10.1080/19420889.2018.1526605
• ISSN: 19420889
• HANDLE: 2115/71776
• Web Site: https://www.tandfonline.com/doi/pdf/10.1080/19420889.2018.1526605
• 本文言語コード: en
• 資料種別: journal article
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