NSD3 keeps IRF3 active
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In this issue of JEM, Wang et al. (https://doi.org/10.1084/jem.20170856) show a novel antiviral innate mechanism by which methyltransferase NSD3 directly monomethylates a transcription factor IRF3 and maintains IRF3 phosphorylation to enhance its transcriptional activity, consequently promoting antiviral innate immune responses.
- The Journal of experimental medicine
The Journal of experimental medicine 214(12), 3475-3476, 2017-12-04
Rockefeller University Press