NSD3 keeps IRF3 active

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Abstract

In this issue of JEM, Wang et al. (https://doi.org/10.1084/jem.20170856) show a novel antiviral innate mechanism by which methyltransferase NSD3 directly monomethylates a transcription factor IRF3 and maintains IRF3 phosphorylation to enhance its transcriptional activity, consequently promoting antiviral innate immune responses.

Journal

  • The Journal of experimental medicine

    The Journal of experimental medicine 214(12), 3475-3476, 2017-12-04

    Rockefeller University Press

Codes

  • NII Article ID (NAID)
    120006534585
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    0022-1007
  • Data Source
    IR 
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