RNA Binding Proteins and Genome Integrity

• Nishida, Kensei

• Kuwano, Yuki

• Nishikawa, Tatsuya

• Masuda, Kiyoshi

• Rokutan, Kazuhito

抄録

Genome integrity can be threatened by various endogenous or exogenous events. To counteract these stressors, the DNA damage response network contributes to the prevention and/or repair of genomic DNA damage and serves an essential function in cellular survival. DNA binding proteins are involved in this network. Recently, several RNA-binding proteins (RBPs) that are recruited to DNA damage sites have been shown to be direct players in the prevention or repair of DNA damage. In addition, non-coding RNAs, themselves, are involved in the RNA-mediated DNA repair system. Furthermore, RNA modification such as m6A methylation might also contribute to the ultraviolet-responsive DNA damage response. Accumulating evidence suggests that RNA metabolism is more deeply involved in diverse cellular functions than previously expected, and is also intricately associated with the maintenance of genome integrity. In this review, we highlight the roles of RBPs in the maintenance of genome integrity.

収録刊行物

• International Journal of Molecular Sciences

  International Journal of Molecular Sciences 18 (7), 1341-, 2017-06-23

  MDPI

キーワード

• RNA-binding protein
• R-loop
• telomere
• DNA damage response

詳細情報

• CRID: 1050564287744850432
• NII論文ID: 120006535039
• NII書誌ID: AA12038549
• ISSN: 14220067
• ISSN: 16616596
• Web Site: https://repo.lib.tokushima-u.ac.jp/112411
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles