8-Prenylnaringenin promotes recovery from immobilization-induced disuse muscle atrophy through activation of the Akt phosphorylation pathway in mice

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Abstract

8-Prenylnaringenin (8-PN) is a prenylflavonoid that originates from hop extracts and is thought to help prevent disuse muscle atrophy. We hypothesized that 8-PN affects muscle plasticity by promoting muscle recovery under disuse muscle atrophy. To test the promoting effect of 8-PN on muscle recovery, we administered an 8-PN mixed diet to mice that had been immobilized with a cast to one leg for 14 days. Intake of the 8-PN mixed diet accelerated recovery from muscle atrophy, and prevented reductions in Akt phosphorylation. Studies on cell cultures of mouse myotubes in vitro demonstrated that 8-PN activated the PI3K/Akt/P70S6K1 pathway at physiologic concentrations. A cell-culture study using an inhibitor of estrogen receptors and an in vivo experiment with ovariectomized mice suggested that the estrogenic activity of 8-PN contributed to recovery from disuse muscle atrophy through activation of an Akt phosphorylation pathway. These data strongly suggest that 8-PN is a naturally occurring compound that could be used as a nutritional supplement to aid recovery from disuse muscle atrophy.

Journal

  • American Journal of Physiology. Regulatory, Integrative and Comparative Physiology

    American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 311(6), R1022-R1031, 2016-12-01

    The American Physiological Society

Codes

  • NII Article ID (NAID)
    120006535072
  • NII NACSIS-CAT ID (NCID)
    AA00521155
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    0363-6119
  • Data Source
    IR 
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