血液透析維持患者のpsychogenic distressの要因～血清脳由来神経栄養因子の観点から～

機関リポジトリ

書誌事項

タイトル別名
  • Factors of Psychogenic Distress in Chronic Hemodialysis Patients:The Impact of Decreased Serum Brain-derived Neurotrophic Factor Levels

この論文をさがす

抄録

Depression, dyssomnia, anxiety, and so-called psychogenic distress (PD) are common in chronic hemodialysis (HD) patients. It was suggested that the PD in the HD patients leads to serious diseases (e.g. cardiovascular disease (CVD), cerebrovascular disease and so on) and to the high mortality rate. Although there were multiple factors of PD by numerous studies, they can be broadly categorized as treatment-related behavioral factors, physical and neurologic. However, the pathophysiology of the PD in the HD patients is poorly understood. Thus, a brain-derived neurotrophic factor (BDNF) was focused; it was one of the key molecules modulating brain plasticity. Cumulative evidence has suggested a link between BDNF and depression. In human studies, the serum BDNF level and BDNF mRNA in the brain decreased in patients with major depression. Incidentally, it showed that serum BDNF in the chronic HD patients was significantly lower than the control group of non-HD patients. Additionally, the prevalence of dyssomnia in the HD patients was the highest in regard to PD, and dyssomnia could lead to the decreased serum BDNF levels according to some studies. Furthermore, as the HD patients were classified into 3 groups by the serum BDNF levels, namely the high, middle and low serum BDNF groups, the high-sensitivity C-reactive protein (hs-CRP) in the low serum BDNF group was higher than those in the other serum BDNF groups. Moreover, the prevalence of CVD in the low serum BDNF group tended to be higher than those in the high serum BDNF group. However, the mechanism remains unresolved at present. It is suggested that further studies are needed to examine the relationship between the serum BDNF level and PD in HD patients.

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ