Even- and odd-chain saturated fatty acids in serum phospholipids are differentially associated with adipokines

• Kurotani, Kayo

  Department of Nutritional Epidemiology and Shokuiku, National Institute of Health and Nutrition | National Institutes of Biomedical Innovation, Health and Nutrition

• Sato, Masao

  Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University

• Yasuda, Kazuki

  Department of Metabolic Disorder, Diabetes Research Center, National Center for Global Health and Medicine

• Kashima, Kentaro

  Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University

• Tanaka, Shoji

  Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University

• Hayashi, Takuya

  Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University

• Shirouchi, Bungo

  Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University

• Akter, Shamima

  Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine

• Kashino, Ikuko

  partment of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine

• Hayabuchi, Hitomi

  Graduate School of Nutrition and Health Science, Fukuoka Women’s University

• Mizoue, Tetsuya

  Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine

Abstract

BACKGROUND: / Saturated fatty acids are generally thought to have detrimental effects on health. However, a recent study showed that even- and odd-chain saturated fatty acids had opposite associations with type 2 diabetes. Limited studies of Western populations examined the associations of circulating saturated fatty acids with adipokines, an important role in glucose metabolism. / OBJECTIVE: / We examined the associations of saturated fatty acids in serum phospholipids with circulating levels of adipokines among a Japanese population. / DESIGN: / A cross-sectional study was conducted among 484 Japanese employees (284 men and 200 women) aged 20-65 years. The serum fatty acid composition in the phospholipid fraction was measured by gas-chromatography. Serum leptin, adiponectin, plasminogen activator inhibitor-1 (PAI-1), resistin, and visfatin were measured using a Luminex suspension bead-based multiplexed array. Multiple linear regression analysis was performed to assess the association between saturated fatty acids and adipokines, with adjustment for potential confounding variables. / RESULTS: / Even- and odd-chain saturated fatty acids were differentially associated with adipokines. Higher levels of even-chain saturated fatty acids (14:0 myristic, 16:0 palmitic, and 18:0 stearic acids) were associated with higher levels of resistin (P for trend = 0.048) and lower levels of adiponectin (P for trend = 0.003). By contrast, odd-chain saturated fatty acids (15:0 pentadecanoic and 17:0 heptadecanoic acids) showed inverse associations with leptin and PAI-1 (P for trend = 0.048 and 0.02, respectively). Visfatin was positively associated with both even- and odd-chain saturated fatty acids. / CONCLUSIONS: / The results suggest that even- and odd-chain saturated fatty acids are differentially associated with adipokine profile.

Journal

• PLoS ONE

  PLoS ONE 12 (5), e0178192-1-e0178192-14, 2017-05-26

  Public Library of Science

Details

• CRID: 1050017057728301184
• NII Article ID: 120006536896
• ISSN: 19326203
• HANDLE: 2324/1958373
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles