β‐carotene suppresses Porphyromonas gingivalis lipopolysaccharide‐mediated cytokine production in THP‐1 monocytes cultured with high glucose condition

• Kajiura, Yukari

• Nishikawa, Yasufumi

• Lew, Jung Hwan

• Kido, Jun-ichi

• Nagata, Toshihiko

• Naruishi, Koji

書誌事項

タイトル別名

• β-Carotene Suppresses Cytokine Production

抄録

Periodontitis is associated with development of diabetes mellitus. Although lipopolysaccharide (LPS) of Porphyromonas gingivalis (Pg), a major pathogen of periodontitis, may lead the progression of diabetes complications, the precise mechanisms are unclear. We, therefore, investigated the effects of β-carotene on production of Pg LPS-induced inflammatory cytokines in human monocytes cultured high glucose (HG) condition. THP-1 cells were cultured under 5.5 mM or 25 mM glucose conditions, and cells were stimulated with Pg LPS. To investigate the productivity of TNF-α, IL-6 and MCP-1, cell supernatants were collected for ELISA. To examine the effects of NF-kB signals on cytokine production, Bay11-7082 was used. HG enhanced Pg LPS-induced production of TNF-α, IL-6 and MCP-1 via NF-kB signals in THP-1. β-carotene suppressed the enhancement of the Pg LPS-induced cytokine production in THP-1 via NF-κB inactivation. Our results suggest that β-carotene might be a potential anti-inflammatory nutrient for circulating Pg LPS-mediated cytokine production in diabetic patients with periodontitis.

収録刊行物

• Cell Biology International

  Cell Biology International 42 (1), 105-111, 2017-10-25

  International Federation for Cell Biology|Wiley

キーワード

• β‐carotene
• diabetic complications
• glucose
• monocyte
• Porphyromonas gingivalis LPS

詳細情報

• CRID: 1050564289008116992
• NII論文ID: 120006539758
• NII書誌ID: AA11544414
• ISSN: 10958355
• Web Site: http://repo.lib.tokushima-u.ac.jp/112503
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
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  • CiNii Articles