Genetic Diversity and Drug Resistance of HIV-1 Circulating in North Sulawesi, Indonesia

• Ueda, Shuhei

• Witaningrum, Adiana Mutamsari

• Khairunisa, Siti Qamariyah

• 小瀧, 将裕

• Nasronudin

• 亀岡, 正典

抄録

Manado, the capital city of North Sulawesi, is a unique region in Indonesia because of its religion. We collected peripheral blood samples from 63 individuals on antiretroviral therapy. The amplification of viral genomic fragments, viral subtyping, detection of HIV drug resistance-associated mutations (DRAMs), and phylogenetic analyses were performed. Viral subtyping revealed that the most prevalent HIV type 1 (HIV-1) subtype/circulating recombinant form (CRF) was CRF01_AE (84.1%), followed by subtype B (6.8%) and recombinants between CRF01_AE and CRF02_AG (4.5%). Although no major DRAMs were present in protease genes, they were detected in reverse transcriptase (RT) genes. Nine of 38 samples (23.7%) had major DRAMs against nucleoside RT inhibitors (NRTIs) and/or non-NRTIs. The results of phylogenetic analyses indicated that CRF01_AE in North Sulawesi is related to that in Bali. Therefore, Bali may play an important role in circulating CRF01_AE in North Sulawesi.

収録刊行物

• AIDS Research and Human Retroviruses

  AIDS Research and Human Retroviruses 35 (4), 407-413, 2019-04

  Mary Ann Liebert, Inc

キーワード

• CRF01_AE
• ART
• North Sulawesi
• Indonesia

詳細情報

• CRID: 1050856995323351936
• NII論文ID: 120006540092
• ISSN: 19318405
• ISSN: 08892229
• HANDLE: 20.500.14094/90005394
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles