Photoinduced electron transfer reaction in mitochondria for spatiotemporal selective photo-oxidation of lipids by donor/acceptor linked molecules

• Takano, Yuta

• Hanai, Erina

• Imahori, Hiroshi

Abstract

Donor-acceptor-linked molecules have been synthesized and utilized to induce the rapid and site-selective lipid-oxidation in mitochondria by utilizing a photoinduced intermolecular electron transfer reaction. Two water-soluble donor-acceptor molecules (1 and 2) were designed and synthesized for this purpose. 2 was prepared to modulate its affinity to cell membrane in mitochondria. Confocal laser microscopy experiments revealed that 1 and 2 possess high localization abilities in mitochondria. By the photoinduced electron transfer, 2 exhibited the remarkable oxidation ability of lipids, mainly cardiolipin. In HeLa cells, 2 triggered mitochondrial lipid oxidation, which was followed by apoptotic cell death, under illumination within a few seconds. These results show that the present molecular system is highly promising to utilize the photoinduced intermolecular electron transfer reaction in a precise spatiotemporal manner in a cell by using light.

Journal

• Nanoscale

  Nanoscale 9 (45), 17909-17913, 2017-12-07

  Royal Society of Chemistry

Keywords

• General Materials Science

Details

• CRID: 1050845763984874240
• NII Article ID: 120006541882
• DOI: 10.1039/c7nr04919f
• ISSN: 20403372
• ISSN: 20403364
• HANDLE: 2115/72134
• Web Site: http://pubs.rsc.org/en/content/articlepdf/2017/NR/C7NR04919F
• Text Lang: en
• Article Type: journal article
• Data Source:
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  • CiNii Articles
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