Peptide Nanospheres Self-Assembled from a Modified β-Annulus Peptide of Sesbania Mosaic Virus

• Matsuura, Kazunori

• Mizuguchi, Yusaku

• Kimizuka, Nobuo

抄録

A novel β-annulus peptide of Sesbania mosaic virus bearing an FKFE sequence at the C terminus was synthesized, and its self-assembling behavior in water was investigated. Dynamic light scattering and transmission electron microscopy showed that the β-annulus peptide bearing an FKFE sequence self-assembled into approximately 30 nm nanospheres in water at pH 3.8, whereas the β-annulus peptide without the FKFE sequence afforded only irregular aggregates. The peptide nanospheres possessed a definite critical aggregation concentration (CAC = 26 μM), above which the size of nanospheres were nearly unaffected by the peptide concentration. The formation of peptide nanospheres was significantly affected by pH; the peptide did not form any assemblies at pH 2.2 whereas larger aggregates were formed at pH 6.4–11.6.

収録刊行物

• Biopolymers. Peptide science

  Biopolymers. Peptide science 106 (4), 470-475, 2015-11-17

  Wiley

キーワード

• viral capsid
• self-assembly
• β-annulus peptide
• nanosphere

詳細情報

• CRID: 1050015354550357504
• NII論文ID: 120006543700
• NII書誌ID: AA11029495
• ISSN: 00063525
• Web Site: https://repository.lib.tottori-u.ac.jp/records/7112
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles