Alkannin inhibits CCL3 and CCL5 production in human periodontal ligament cells

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Abstract

Alkannin, which is found in Alkanna tinctoria, a member of the borage family, is used as a food coloring. Alkannin has recently been reported to have certain biological functions, such as anti-microbial and anti-oxidant effects. It is known that CC chemokine receptor (CCR) 5-positive leukocytes contribute to alveolar bone resorption in periodontal lesions. The aim of this study was to examine whether alkannin inhibits the production of CC chemokine ligand (CCL) 3 and CCL5, which are CCR5 ligands, in human periodontal ligament cells (HPDLC). Interleukin (IL)-1β induced CCL3 and CCL5 production in HPDLC. Alkannin inhibited IL-1β-mediated CCL3 and CCL5 production in HPDLC in a dose-dependent manner. Moreover, we revealed that alkannin suppressed inhibitor of kappa B-α degradation in IL-1β-stimulated HPDLC. In addition, a nuclear factor (NF)-κB inhibitor significantly inhibited CCL3 and CCL5 production in IL-1β-stimulated HPDLC. These results demonstrate that alkannin inhibits CCR5 ligand production in IL-1β-stimulated HPDLC by attenuating the NF-κB signaling pathway.

Journal

  • Cell Biology International

    Cell Biology International 40(12), 1380-1385, 2016-10-24

    International Federation for Cell Biology|Wiley

Codes

  • NII Article ID (NAID)
    120006543828
  • NII NACSIS-CAT ID (NCID)
    AA10882014
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    1065-6995
  • Data Source
    IR 
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