Shikonin Inhibits Inflammatory Cytokine Production in Human Periodontal Ligament Cells

• Shindo, Satoru

• Hosokawa, Yoshitaka

• Hosokawa, Ikuko

• Ozaki, Kazumi

• Matsuo, Takashi

書誌事項

タイトル別名

• Shikonin inhibits inflammatory cytokine production

抄録

Shikonin, which is derived from Lithospermum erythrorhizon, a herb used in traditional medicine, has long been considered to be a useful treatment for various diseases in traditional oriental medicine. Shikonin has recently been reported to have several pharmacological properties, e.g., it has anti-microbial, anti-tumor, and anti-inflammatory effects. The aim of this study was to examine whether shikonin is able to influence the production of interleukin (IL)-6, IL-8, and/or chemokine C-C motif ligand (CCL)20, which contribute to the pathogenesis of periodontal disease, in human periodontal ligament cells (HPDLC). The production levels of IL-6, IL-8, and CCL20 in HPDLC were determined using an ELISA. Western blot analysis was used to detect nuclear factor kappa B (NF-κB) pathway activation in HPDLC. Shikonin prevented IL-1β- or tumor necrosis factor (TNF)-α-mediated IL-6, IL-8, and CCL20 production in HPDLC. Moreover, we found that shikonin suppressed the phosphorylation and degradation of inhibitor of kappa B-alpha (IκB-α) in IL-1β- or TNF-α-stimulated HPDLC. These findings suggest that shikonin could have direct beneficial effects against periodontal disease by reducing IL-6, IL-8, and CCL20 production in periodontal lesions.

収録刊行物

• Inflammation

  Inflammation 39 (3), 1124-1129, 2016-04-12

  Springer

キーワード

• shikonin
• IL-6
• IL-8
• CCL20
• NF-κB
• periodontal ligament cells

詳細情報

• CRID: 1050001337821723776
• NII論文ID: 120006543829
• NII書誌ID: AA00673765
• ISSN: 03603997
• ISSN: 15732576
• DOI: 10.1007/s10753-016-0344-0
• Web Site: http://repo.lib.tokushima-u.ac.jp/112814
• Web Site: http://link.springer.com/content/pdf/10.1007/s10753-016-0344-0.pdf
• Web Site: http://link.springer.com/article/10.1007/s10753-016-0344-0/fulltext.html
• Web Site: http://link.springer.com/content/pdf/10.1007/s10753-016-0344-0
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
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