Gomisin N Decreases Inflammatory Cytokine Production in Human Periodontal Ligament Cells

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Abstract

Gomisin N, which is a lignan isolated from Schisandra chinensis, has some pharmacological effects. However, the anti-inflammatory effects of gomisin N on periodontal disease are uncertain. The aim of this study was to examine the effect of gomisin N on inflammatory mediator production in tumor necrosis factor (TNF)-α-stimulated human periodontal ligament cells (HPDLC). Gomisin N inhibited interleukin (IL)-6, IL-8, CC chemokine ligand (CCL) 2, and CCL20 production in TNF-α-stimulated HPDLC in a dose-dependent manner. Moreover, we revealed that gomisin N could suppress extracellular signal-regulated kinase (ERK) and c-Jun N terminal kinase (JNK) phosphorylation in TNF-α-stimulated HPDLC though protein kinase B (Akt) phosphorylation was not suppressed by gomisin N treatment. In summary, gomisin N might exert antiinflammatory effects by attenuating cytokine production in periodontal ligament cells via inhibiting the TNF-α-stimulated ERK and JNK pathways activation.

Journal

  • Inflammation

    Inflammation 40(2), 360-365, 2016-11-28

    Springer

Codes

  • NII Article ID (NAID)
    120006543831
  • NII NACSIS-CAT ID (NCID)
    AA00673765
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    0360-3997
  • Data Source
    IR 
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