Generation and Applications of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells

• 池谷, 真

  Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University

• Ikeya, Makoto

  Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University

抄録

Mesenchymal stem cells (MSCs) are adult stem cells with fibroblast-like morphology and isolated from the bone marrow via plastic adhesion. Their multipotency and immunoregulatory properties make MSCs possible therapeutic agents, and an increasing number of publications and clinical trials have highlighted their potential in regenerative medicine. However, the finite proliferative capacity of MSCs limits their scalability and global dissemination as a standardized therapeutic product. Furthermore, adult tissue provenance could constrain accessibility, impinge on cellular potency, and incur greater exposure to disease-causing pathogens based on the donor. These issues could be circumvented by the derivation of MSCs from pluripotent stem cells. In this paper, we review methods that induce and characterize MSCs derived from induced pluripotent stem cells (iPSCs) and introduce MSC applications to disease modeling, pathogenic mechanisms, and drug discovery. We also discuss the potential applications of MSCs in regenerative medicine including cell-based therapies and issues that should be overcome before iPSC-derived MSC therapy will be applied in the clinic.

収録刊行物

• Stem Cells International

  Stem Cells International 2018 1-8, 2018-07-31

  Hindawi Limited

キーワード

• Cell Biology
• Molecular Biology

詳細情報

• CRID: 1050845763139295488
• NII論文ID: 120006547375
• ISSN: 16879678
• ISSN: 1687966X
• DOI: 10.1155/2018/9601623
• HANDLE: 2433/235936
• Web Site: http://downloads.hindawi.com/journals/sci/2018/9601623.pdf
• Web Site: http://downloads.hindawi.com/journals/sci/2018/9601623.xml
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN