Synthesis of CPZEN-45: Construction of the 1,4-Diazepin-2-one Core by the Cu-Catalyzed Intramolecular Amidation of a Vinyl Iodide

• 中村, 斐有

  Graduate School of Pharmaceutical Sciences, Kyoto University

• 吉田, 拓馬

  Graduate School of Pharmaceutical Sciences, Kyoto University

• 塚野, 千尋

  Graduate School of Pharmaceutical Sciences, Kyoto University

• 竹本, 佳司

  Graduate School of Pharmaceutical Sciences, Kyoto University

抄録

CPZEN-45 was developed as an antibiotic against Mycobacterium tuberculosis by the chemical modification of caprazamycins. CPZEN-45 has been synthesized in this study by the Cu-catalyzed intramolecular amidation of a complex vinyl iodide precursor bearing uridine and sugar moieties with a secondary amide, allowing for the construction of its 1, 4-diazepin-2-one core.

収録刊行物

• Organic Letters

  Organic Letters 18 (9), 2300-2303, 2016-05-06

  American Chemical Society

キーワード

• Organic Chemistry
• Physical and Theoretical Chemistry
• Biochemistry

詳細情報

• CRID: 1050282813185876096
• NII論文ID: 120006547379
• ISSN: 15237052
• ISSN: 15237060
• DOI: 10.1021/acs.orglett.6b00943
• HANDLE: 2433/235940
• Web Site: https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.6b00943
• 本文言語コード: en
• 資料種別: journal article
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