A study of girls with PMLD in the special school: a possible involvement of estrogen-induced release of serotonin in the subfornical organ

• 田中 淳一

• 高橋 眞琴

• TANAKA Junichi

• TAKAHASHI Makoto

抄録

Children with Profound and Multiple Learning Difficulties/Disabilities (PMLD) belong to special schools dealing with physical difficulties in Japan and almost of them have cerebral palsy. Typical symptoms are spasticity, epilepsy, mental retardation, learning disabilities and ataxia. Sometimes they have a strong behavioral disorder (Bellamy et al, 2010). In this study, we attempt to speculate that the 5-HT release from the SFO may participate in the cases of behavioral disorders of three PMLD girls who belong to a special school. Our speculation also may offer to explain the relationship between their behavioral disorders and changes in plasma 5-HT and/or estrogen. From the three cases and previous findings lead to the hypothesis that the levels of 5-HT levels regulating by estrogen in the PMLD children brains may be implicated in the any disorder. In addition, our speculations imply that it may necessary to measure regularly the either plasma 5-HT or estrogen levels in the PMLD children for controlling a wrong behavior.

収録刊行物

• 鳴門教育大学研究紀要

  鳴門教育大学研究紀要 33 92-95, 2018-02-15

  鳴門教育大学

キーワード

• Profound and Multiple Learning Difficulties/Disabilities
• estrogen
• subfornical organ

詳細情報

• CRID: 1390572174799212672
• NII論文ID: 40021471295
• NII論文ID: 120006554146
• NII書誌ID: AA12124651
• DOI: 10.24727/00027997
• ISSN: 18807194
• NDL書誌ID: 028836436
• Web Site: https://naruto.repo.nii.ac.jp/records/28003
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I028836436
• 本文言語コード: en
• データソース種別:
  • JaLC
  • IRDB
  • NDL
  • CiNii Articles