Photocatalytic N-Methylation of Amines over Pd/TiO2 for the Functionalization of Heterocycles and Pharmaceutical Intermediates
Abstract
Amines in heteroaromatic systems and pharmaceutical intermediates were functionalized through N-methylation with methanol using a palladium-loaded titanium dioxide (Pd/TiO2) photocatalyst. This method provides access to a series of tertiary N-methylamines bearing N-, O-, and/or S-containing heteroaromatic functionalities from primary/secondary amines and methanol under mild reaction conditions. Facile syntheses of several pharmaceuticals containing N-methyl or ethyl groups, as well as related deuterated drugs, was achieved through the late-stage functionalization of amines.
Journal
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- ACS Sustainable Chemistry & Engineering
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ACS Sustainable Chemistry & Engineering 6 (11), 15419-15424, 2018-11-05
ACS Publications
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Details 詳細情報について
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- CRID
- 1050001338813865472
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- NII Article ID
- 120006577073
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- ISSN
- 21680485
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- HANDLE
- 2237/00029385
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- IRDB
- CiNii Articles