Direct Synthesis of Lactams from Keto Acids, Nitriles, and H₂ by Heterogeneous Pt Catalysts

• Siddiki, S. M. A. H.

• Touchy, Abeda S.

• Bhosale, Ashvini

• Toyao, Takashi

• Mahara, Yuji

• Ohyama, Junya

• Satsuma, Atsushi

• Shimizu, Ken-ichi

書誌事項

タイトル別名

• Direct Synthesis of Lactams from Keto Acids, Nitriles, and H-2 by Heterogeneous Pt Catalysts

抄録

We report herein the first general catalytic system for the direct synthesis of N-substituted gamma- and delta-lactams by reductive amination/cyclization of keto acids (including levulinic acid) with nitriles and H-2 under mild conditions (7bar H-2, 110 degrees C, solvent free). The most effective catalyst, Pt and MoOx co-loaded TiO2 (Pt-MoOx/TiO2), shows a wide substrate scope, high turnover number (TON), and good reusability.

収録刊行物

• ChemCatChem

  ChemCatChem 10 (4), 789-795, 2018-02-21

  Wiley-Blackwell

キーワード

• amination
• hydrogenation
• keto acids
• nitriles
• platinum

詳細情報

• CRID: 1050845763987683200
• NII論文ID: 120006577373
• DOI: 10.1002/cctc.201701355
• ISSN: 18673899
• ISSN: 18673880
• HANDLE: 2115/72830
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcctc.201701355
• Web Site: https://onlinelibrary.wiley.com/doi/full/10.1002/cctc.201701355
• 本文言語コード: en
• 資料種別: journal article
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