Structural and Biochemical Studies on the Reaction Mechanism of Uridine-Cytidine Kinase

• Tomoike, Fumiaki

• Nakagawa, Noriko

• Kuramitsu, Seiki

• Masui, Ryoji

抄録

Uridine–cytidine kinase catalyzes phosphorylation of the pyrimidine nucleosides uridine and cytidine and plays an important role in nucleotide metabolism. However, the detailed molecular mechanism of these reactions remains to be elucidated. Here, we determined the structure of the ternary complex of uridine–cytidine kinase from Thermus thermophilus HB8 with both cytidine and β,γ-methyleneadenosine 5'-triphosphate, a non-hydrolysable ATP analogue....

収録刊行物

• The Protein Journal

  The Protein Journal 34 (6), 411-420, 2015-12

  Springer

キーワード

• Uridine–cytidine kinase
• Phosphate transfer
• Crystal structure
• Mutational study
• Pyrimidine nucleoside
• pH dependence

詳細情報

• CRID: 1050282677431833088
• NII論文ID: 120006577675
• NII書誌ID: AA1211041X
• ISSN: 15734943
• ISSN: 18758355
• ISSN: 15723887
• DOI: 10.1007/s10930-015-9636-8
• Web Site: https://dlisv03.media.osaka-cu.ac.jp/il/meta_pub/G0000438repository_15734943-34-6-411
• Web Site: https://link.springer.com/content/pdf/10.1007/s10930-015-9636-8.pdf
• Web Site: https://link.springer.com/article/10.1007/s10930-015-9636-8/fulltext.html
• Web Site: http://link.springer.com/content/pdf/10.1007/s10930-015-9636-8
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
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