Structural and Biochemical Studies on the Reaction Mechanism of Uridine-Cytidine Kinase
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Abstract
Uridine–cytidine kinase catalyzes phosphorylation of the pyrimidine nucleosides uridine and cytidine and plays an important role in nucleotide metabolism. However, the detailed molecular mechanism of these reactions remains to be elucidated. Here, we determined the structure of the ternary complex of uridine–cytidine kinase from Thermus thermophilus HB8 with both cytidine and β,γ-methyleneadenosine 5'-triphosphate, a non-hydrolysable ATP analogue....
Journal
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- The Protein Journal
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The Protein Journal 34 (6), 411-420, 2015-12
Springer
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Keywords
Details 詳細情報について
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- CRID
- 1050282677431833088
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- NII Article ID
- 120006577675
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- NII Book ID
- AA1211041X
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- ISSN
- 15734943
- 18758355
- 15723887
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- IRDB
- Crossref
- CiNii Articles
- KAKEN