Administration of constituent amino acids of type I collagen stimulates collagen-induced arthritis in DBA/1J mice.

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  • DBA/1J マウスにおけるI 型コラーゲン構成アミノ酸によるコラーゲン誘導性関節炎の誘発促進
  • DBA/1Jマウス ニ オケル Ⅰ カタ コラーゲン コウセイ アミノサン ニ ヨル コラーゲン ユウドウセイ カンセツエン ノ ユウハツ ソクシン

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Abstract

Supplementation of gelatin or collagen peptides has been used to reduce the symptoms of inflammatory arthritis including rheumatoid arthritis, but the efficacy remains uncertain. It is known that ingested collagen peptides are absorbed partly in the form of bioactive peptides. In the present study, we investigated whether the effects of collagen peptide on inflammatory arthritis are due to its bioactive peptide in comparison with its constituent amino acids using DBA/1J mice. Unexpectedly, administration of daily 100 mg of collagen peptide derived from chicken type I collagen (i.e., collagen peptide group) or its constituent amino acids (i.e., amino acid group) rather stimulated collagen-induced arthritis in the DBA/1J mice. No significant difference was observed between amino acid and collagen peptide groups regarding either arthritis score or gene expression of matrix metalloprotease 3 (MMP3), a marker of synovial inflammation. Further, mice in the amino acid group developed arthritis relatively early stage and showed significantly higher expression of MMP13 as compared to those in other group mice, indicating administration of collagen-constituent amino acids possibly promoted the onset of arthritis inflammation in the DBA/1J mice. Many supplements contain gelatin or collagen peptide derived from type I collagen. These results raise a possibility that type I collagen peptide or its constituent amino acid may worsen inflammatory arthritis under some conditions.

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