Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice
抄録
金沢大学医薬保健研究域医学系
Oxytocin sets the stage for childbirth by initiating uterine contractions, lactation and maternal bonding behaviours. Mice lacking secreted oxcytocin (Oxt -/-, Cd38 -/-) or its receptor (Oxtr -/-) fail to nurture. Normal maternal behaviour is restored by peripheral oxcytocin replacement in Oxt -/- and Cd38 -/-, but not Oxtr -/- mice, implying that circulating oxcytocin crosses the blood-brain barrier. Exogenous oxcytocin also has behavioural effects in humans. However, circulating polypeptides are typically excluded from the brain. We show that oxcytocin is transported into the brain by receptor for advanced glycation end-products (RAGE) on brain capillary endothelial cells. The increases in oxcytocin in the brain which follow exogenous administration are lost in Ager -/- male mice lacking RAGE, and behaviours characteristic to abnormalities in oxcytocin signalling are recapitulated in Ager -/- mice, including deficits in maternal bonding and hyperactivity. Our findings show that RAGE-mediated transport is critical to the behavioural actions of oxcytocin associated with parenting and social bonding.
30820471
収録刊行物
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- Communications Biology
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Communications Biology 2 76-, 2019-02-25
Nature Research
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詳細情報 詳細情報について
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- CRID
- 1390009225198972288
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- NII論文ID
- 120006605138
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- ISSN
- 23993642
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- Web Site
- http://hdl.handle.net/2297/00053843
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- en
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