眼球毒性の観察された農薬についての文献的考察

• 義澤 克彦

• 金瀬 茜

• 行光 由莉

• 新家 由実子

• 平塚 未夢

• 平山 由佳理

• 三浦 麻里安

• 榎本 祐子

• 小山 千尋

• 竹之内 明子

• Katsuhiko Yoshizawa

• Akane Kanase

• Yuri Yukimitsu

• Yumiko Shinke

• Miyu Hiratsuka

• Yukari Hirayama

• Maria Miura

• Yuko Emoto

• Chihiro Koyama

• Akiko TAKENOUCHI

Abstract

Pesticides evaluated previously by the Food Safety Commission of the Cabinet Office, Japan were in vestigated retrospectively for induction of ocular toxicity. A total of 339 assessment reports representing 345 compounds were investigated. Ocular toxicity was observed in 56 compounds. Target sites were pupils for 21 compounds, retinas for 21 compounds, lenses for 16 compounds, corneas for 15 compounds, conjunctiva for 3 compounds and whole eyeballs for 2 compounds. These ocular toxicities were not related to local irritation, but were due to systemic exposure after oral absorption. For many of these compounds, the mechanism (s) of ocular toxicities are unknown. Ocular toxicities were only induced at considerably higher doses of exposure compared to the acceptable daily intake (ADI) with sufficient safety margins for ocular toxicity. Although it is unlikely that ocular toxicities induced by these chemicals will occur in humans, it is though that future studies anticipating actual human exposure conditions and associated pharmacokinetic information will be important.

Journal

• 武庫川女子大学紀要. 自然科学編

  武庫川女子大学紀要. 自然科学編 66 1-8, 2019-03-31

  [出版社不明]

Details

• CRID: 1390853650129144832
• NII Article ID: 120006621868
• NII Book ID: AN10187277
• ISSN: 09163123
• DOI: 10.14993/00001495
• Web Site: http://id.nii.ac.jp/1479/00001495/
• Web Site: https://search.jamas.or.jp/link/ui/2019201441
• Text Lang: ja
• Data Source:
  • JaLC
  • IRDB
  • CiNii Articles
  • KAKEN