A femtomolar-range suicide germination stimulant for the parasitic plant <i>Striga hermonthica</i>

• Uraguchi, Daisuke

• Kuwata, Keiko

• Hijikata, Yuh

• Yamaguchi, Rie

• Imaizumi, Hanae

• AM, Sathiyanarayanan

• Rakers, Christin

• Mori, Narumi

• Akiyama, Kohki

• Irle, Stephan

• McCourt, Peter

• Kinoshita, Toshinori

• Ooi, Takashi

• Tsuchiya, Yuichiro

書誌事項

タイトル別名

• A femtomolar-range suicide germination stimulant for the parasitic plant Striga hermonthica

抄録

The parasitic plant Striga hermonthica has been causing devastating damage to the crop production in Africa. Because Striga requires host-generated strigolactones to germinate, the identification of selective and potent strigolactone agonists could help control these noxious weeds. We developed a selective agonist, sphynolactone-7, a hybrid molecule originated from chemical screening, that contains two functional modules derived from a synthetic scaffold and a core component of strigolactones. Cooperative action of these modules in the activation of a high-affinity strigolactone receptor ShHTL7 allows sphynolactone-7 to provoke Striga germination with potency in the femtomolar range. We demonstrate that sphynolactone-7 is effective for reducing Striga parasitism without impinging on host strigolactone-related processes.

収録刊行物

• Science

  Science 362 (6420), 1301-1305, 2018-12-14

  American Association for the Advancement of Science

キーワード

• Multidisciplinary

詳細情報

• CRID: 1050845763744086912
• NII論文ID: 120006623828
• DOI: 10.1126/science.aau5445
• ISSN: 10959203
• ISSN: 00368075
• HANDLE: 2237/00030159
• Web Site: https://nagoya.repo.nii.ac.jp/records/27961
• Web Site: https://syndication.highwire.org/content/doi/10.1126/science.aau5445
• Web Site: https://www.science.org/doi/pdf/10.1126/science.aau5445
• 本文言語コード: en
• 資料種別: journal article
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