Aerobic exercise training and dehydroepiandrosterone administration increase testicular sex steroid hormones and enhance reproductive function in high-sucrose-induced obese rats

• Tatara, Koki

• 佐藤, 幸治

抄録

This study assessed the effects of chronic dehydroepiandrosterone (DHEA) administration and exercise training on testicular sex steroid hormone levels and reproductive function in high-sucrose induced obese rats. After 14 weeks of a high-sucrose diet, Wistar male rats were assigned randomly to the control, exercise training (running at 25 m/min for 1 h, 5 days/week), DHEA administration, and combined exercise training and DHEA administration groups (n = 7 each group). Six weeks of DHEA administration and/or exercise training significantly increased plasma concentrations of DHEA and 5α-dihydrotestosterone (DHT) and epididymis DHEA concentrations; however, the expression of steroidogenic enzymes, such as 3β-hydroxysteroid dehydrogenase (HSD), 17β-HSD, and 5α-reductase, did not change following any interventions. Procathepsin L expression, which involved sperm maturation, was significantly lower in the DHEA and combination groups, and glutathione peroxidase 4 (GPx4) expression, which plays a role in protecting sperms from oxidative stress, was significantly increased in the DHEA administration group. Additionally, exercise training and/or DHEA administration-induced increase in procathepsin L expressions were significantly correlated with the epididymis DHEA concentrations. These findings suggest that exercise training and/or DHEA administration-induced increase in epididymis DHEA concentration may improve impairment of reproductive function in high-sucrose obese rats. Additionally, exercise training and/or DHEA administration-induced increase in DHEA concentration may have a role in testicular-specific action, which included protective role from exercise-induced oxidant damage as well as contributed to the enhancement of sperm modification and maturation in obese rats.

収録刊行物

• The Journal of Steroid Biochemistry and Molecular Biology

  The Journal of Steroid Biochemistry and Molecular Biology 190 37-43, 2019-06

  Elsevier

キーワード

• Epididymis
• Sperm protection
• Sperm growth
• Steroid

詳細情報

• CRID: 1050294045369599616
• NII論文ID: 120006629275
• NII書誌ID: AA1077779X
• HANDLE: 20.500.14094/90005950
• ISSN: 09600760
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles