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Abstract

Cancer cells often secrete extracellular vesicles (EVs) that carry heat shock proteins (HSPs) with roles in tumor progression. Oral squamous cell carcinoma (OSCC) belongs to head and neck cancers (HNC) whose lymph-node-metastases often lead to poor prognosis. We have examined the EV proteome of OSCC cells and found abundant secretion of HSP90-enriched EVs in lymph-node-metastatic OSCC cells. Double knockdown of HSP90α and HSP90β, using small interfering RNA significantly reduced the survival of the metastatic OSCC cells, although single knockdown of each HSP90 was ineffective. Elevated expression of these HSP90 family members was found to correlate with poor prognosis of HNC cases. Thus, elevated HSP90 levels in secreted vesicles are potential prognostic biomarkers and therapeutic targets in metastatic OSCC.

Journal

  • Journal of Cellular Biochemistry

    Journal of Cellular Biochemistry 119(9), 7350-7362, 2018-05-16

    Wiley

Codes

  • NII Article ID (NAID)
    120006629820
  • NII NACSIS-CAT ID (NCID)
    AA1052210X
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    0730-2312
  • Data Source
    IR 
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