Neurotropin inhibits neuronal activity through potentiation of sustained Kv currents in primary cultured DRG neurons

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  • 河合, 洋幸
    Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
  • 淺岡, 希美
    Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
  • 三宅, 崇仁
    Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
  • 永安, 一樹
    Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
  • 中川, 貴之
    Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital
  • 白川, 久志
    Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
  • 金子, 周司
    Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University

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Neurotropin (NTP) is a Japanese analgesic agent for treating neuropathic pain; however, its method of action remains unclear. This study examined the effects of NTP on the activity of small dorsal root ganglion (DRG) neurons using whole-cell patch clamp recordings. After 3 days of treatment, NTP decreased current injection-induced firing activity of cultured DRG neurons by raising the current threshold for action potential generation. Additionally, NTP increased the sustained component of voltage-gated potassium (Kv) channel currents without affecting other K⁺ currents. These results suggest that NTP inhibits the firing activity of DRG neurons through augmentation of sustained Kv current.

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